By Jeffrey M. Drazen (auth.), Zeliha Yazici, Giancarlo C. Folco, Jeffrey M. Drazen, Santosh Nigam, Takao Shimizu (eds.)
This quantity, the lawsuits of the twelfth foreign convention on Advances in Prostaglandin, Leukotriene and different Bioactive Lipid learn: simple technology and medical functions, held August 25-29, 2002, in Istanbul, Turkey, discusses advances in bioactive lipid study with exact recognition to melanoma, cardiovascular ailments, gastrointestinal ailments and respiration illnesses. particular issues coated contain the position of leukotrienes and lipoxins in irritation, the cytochrome P450 pathway, the genetics and genomics of bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors.
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Extra resources for Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research: Basic Science and Clinical Applications
5 Drazen 1M, Yandava C, Dube L, Szczerback N, Hippensteel R, Pillari A et al. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment Nature Genetics 1999; 22:170-172. Asano K, Shiomi T, Hasegawa N, Nakamura H, Kudo H, Matsuzaki T et aI. Leukotriene C4 synthase gene A(-444)C polymorphism and clinical response to a CYS-LTl antagonist, in Japanese patients with moderate asthma. Pharmacogenetics 2002; 12:1-6. Bleecker ER, Welch MJ, Weinstein SF, Kalberg C, Johnson M, Edwards L et al.
Significant reductions in volume of the lesions and improved physiological functions were found in rats subjected to transient MCA occlusion and treated with anti-ICAM antibody, as well as with selective PMNL depletion in a murine model of reperfused stroke. The interaction between EC and PMNL represents a unique site of biosynthesis of cysteinyl-leukotrienes (cys-LT), according to a process termed ''transcellular biosynthesis". The unstable intermediate LT~, made available by activated PMNL, can be captured by the juxtaposed EC and converted to cys-LT.
Sala A, S Zarini, M Bolla Leukotrienes: lipid bioeffectors of inflammatory reactions. Biochemistry (Moscow) 1998; 63(1): pp. 84-92. Demoly P et aI. IgE produces monocyte superoxide anion release: correlation with CD23 expression. Comparison of patients with asthma, patients with rhinitis, and normal subjects. J Allergy Clin Immunol1994; 93(1 Pt I) : 108-116. Ferreri NR, WC Howland, HL Spiegelberg. Release of leukotrienes C4 and B4 and prostaglandin E2 from human monocytes stimulated with aggregated IgG, IgA, and IgE.