Biopharmaceutical Drug Design and Development Second Edition by Susanna Wu-Pong, Yon Rojanasakul

By Susanna Wu-Pong, Yon Rojanasakul

This booklet presents a entire exam of the latest biopharmaceutical medicinal drugs. one of the medications mentioned are ones within the different types of monoclonal antibodies for in-vivo use, cytokines, progress elements, enzymes, immunomodulators, thrombolytics, and immonotherapies together with vaccines. also, the amount examines new and rising applied sciences, and features a assessment of the Human Genome venture.

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These tools have been enhanced by the growth of the Internet which has allowed rapid global access to computational tools and databases. Bioinformatics is a new field that has emerged from this need to use and manage these databases. This topic, though inexorably linked to the results of the HGP, is discussed in Chapter 3. 7. Transfer of Technologies to the Private Sector/Implications As mentioned earlier, an important feature of the HGP is the translation of sequence information into discoveries that could benefit society or healthcare.

Hann, M. M. and aprea, T. 1. (2004) Pursuing the lead1ik:eness concept in pharmaceutical research. Curro Opin. Chern. BioI. 8, 255-263. 4. , Ross, D. , et al. (2000) A gene expression database for the molecular pharmacology of cancer. Nature Genet. 24(3),236-244. 5. Ross, D. , Eisen, M. , et al. (2000) Systematic variation in gene expression patterns in human cancer cell lines. Nat. Genet. 24(3), 227-235. 6. , Huang, Y, and Sadee, W. (2006) Prediction of anticancer drug potency from expression of genes involved in growth factor signaling.

As mentioned earlier, differential expression is a valuable approach in identifying genes that behave differently in disease, yet the actual role of that gene in the disease is critical in determining its importance as a potential drug target. A gene's cellular function and role in disease is determined using an experimental approach. Specific downregulation of a gene, first in cell lines, then in wild-type animal and transgenic models, is necessary to determine the protein's function and thus, appropriateness for development as a drug target.

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