Caffeine: Perspectives from Recent Research by M. J. Arnaud (auth.), P. B. Dews (eds.)

By M. J. Arnaud (auth.), P. B. Dews (eds.)

Before the past due Nineteen Seventies, curiosity in caffeine between either most of the people and the medical group used to be at a comparatively low point for a few years, although it was once famous that caffeine was once an al­ such a lot common component to the nutrition. The nationwide espresso Associa­ tion was once assisting a continuous application of study, a few re­ seek was once being carried out by means of a number of the greatest businesses promoting espresso, and an occasional college researcher grew to become inter­ ested in caffeine and carried out experiments, frequently on results of caf­ feine in very excessive focus in vitro on skeletal muscle fibres or on dividing cells. due to the fact 1978, despite the fact that, there was a amazing up­ surge in either public and clinical curiosity in caffeine. it truly is curiosity­ ing to notice that this was once triggered now not by way of discovery of hitherto un­ recognized results or dangers of caffeine, yet by means of the activities of a regulatory organisation, the nutrition & Drug management (FDA) of the U. S. Public well-being carrier. The U. S. Congress handed new legislation on meals and medicine in 1958. one of many provisions was once for checking out of meals ingredients to evaluate hazard to healthiness. because it used to be essentially impracticable to require speedy attempt­ ing of all ingredients already in use, a listing used to be drawn up of a few hun­ dreds of additions that have been usually famous as secure (GRAS).

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J Lab Clin Med 2: 1-15 Berthemot, Dechastelus (1840) Chemische Untersuchung des Guarana. Liebigs Ann Chern 36: 90-93 Birkett OJ, Grygiel JJ, Miners JO (1981) Metabolic disposition of the methylxanthines in man. In: RietbrockN, WoodcockBG, StaibAH, (eds) Methods in clinical pharmacology, vo13. Vieweg, Braunschweig Wiesbaden, pp 149-158 Bonati M, Latini R, Marzi E, Cantoni R, Belvedere G (1980) [2_14C] caffeine metabolism in control and 3-methylcholanthrene induced rat liver microsome by high pressure liquid chromatography.

1981) administered [8- 14C]caffeine to adult male chimpanzees, rhesus monkeys, and galagos and collected their urine and feces for 24 h. Although only 38%-56% of the dose was recovered in urine and less than 1% in feces, this study showed extensive metabolism of caffeine, less than 1% being excreted unchanged. The metabolites, separated into methylxanthines and methyl uric acids, were shown to differ appreciably between the species, and trimethyluric acid was always a minor metabolite (3%-6%).

Caffeine metabolism in the newborn child was studied using a chloroform-isopropanol extraction procedure to isolate the urinary metabolites and a HPLC system which separated caffeine and 13 metabolites (Aldridge et al. 1979). Caffeine was more than 85% of the identified metabolites in the newborn, but this percentage decreased to the adult value by the age of 7-9 months. This study demonstrated that the limited capacity for caffeine metabolism in the newborn and the slow urinary excretion of unchanged caffeine explained the 4-day plasma half-life which characterized these newborns.

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