Calcium Regulation by Calcium Antagonists by Ralf G. Rahwan & Donald T. Witiak

By Ralf G. Rahwan & Donald T. Witiak

content material: Calcium antagonists : type and homes / Winifred G. Nayler --
Chemical pharmacology of calcium antagonists / D.J. Triggle --
results of calcium inhibitory compounds upon the cardiovascular procedure / William W. Muir --
keep an eye on of intracellular calcium in soft muscle / E.E. Daniel, A.K. Grover, and C.Y. Kwan --
Calmodulin : an intracellular Ca² receptor protein / Charles O. Brostrom, Margaret A. Brostrom, and Donald J. Wolff --
Pharmacology of intracellular calcium opposed methylenedioxyindenes / Ralf G. Rahwan and Donald T. Witiak --
Pharmacologic results of calcium interactions with opioid alkaloids and peptides / David Chapman and E. Leong approach --
Calcium antagonism and antiepileptic medications / James A. Ferrendelli --
courting of cyclic nucleotides and calcium in platelet functionality / G.C. Le Breton, N.E. Owen, and H. Feinberg --
Suppression of atherogenesis with a membrane-active agent : nifedipine / Philip D. Henry and Karen Bentley --
Calcium and the secretory technique / J.L. Borowitz, David E. Seyler, and Celeste C. Kuta.

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Ch003 Lidoflazine C H , 0 - ( ( CH, I CHtCH,), 1 J V C ^ C H J N C H J C H J C H J C C N CHjO OCH, AH, Verapamil Diazoxide 0CH5 CHjOC 11 > ^ H CO- COCM. II * ΗΊ 3 ο 1 ο -NO, Ο Γ W Τ ι KjCCHjCHjOCMjCHjOl>c y cocMjCH ocM,cH CMj 2 2 lOL Tiapamil Niludipine Figure 2. Structural formulas of some calcium inhibitory compounds. Continued on next page. Perhexiline 3. ch003 AHR-2666 OCM, CH -CH2-ço 2 ù ùr* -CHOH Ç H j NH-CjH 7 Propafenone Diltiazem ^^-CMCH 2 CH 2 CM. NHCHicH -^^ CM. t 2-n-Butyl Methylenedioxyindene (MDl) Prenylamine OH OH CH,, OS [OH , ,0 à Figure 2.

2 2 + O t h e r S i t e s Of A c t i o n 2 + Although the C a - e n t r y blockers a r e , with j u s t i f i c a t i o n , known t o i n h i b i t s p e c i f i c C a m o b i l i z a t i o n processes they can i n h i b i t o t h e r e v e n t s i n c l u d i n g i o n movements and r e c e p t o r b i n d i n g ( 9 , 2 3 , 6 0 ) . Such a d d i t i o n a l p r o p e r t i e s may c o n t r i b u t e t o the s p e c t r u m o f p h a r m a c o l o g i c and t h e r a p e u t i c a c t i v i t i e s o f these agents.

Acad. S c i . , 1981, 78, 1227-1241. ; Hornung, R. Mol. C e l l . , 1980, 19, 243-251. ; C a t t e r a l l , W. Mol. , 1979, 15, 174178. , Mol. , 1979, 15, 174-178. , J. Gen. Physiol. 1975, 6 6 , 169-182. ; Herchuelz, H. Biochem. Pharma­ col. 1981, 30, 3291-3294. , J. Physiol. Paris. 1980, 76, 515-522. ; Parker, I . , Proc. Roy. Soc. Lond. , 1980, 211, 143-150. ; Parker, I . , Biomed. , 1981, 2, 587-589. RECEIVED June 10, 1982. 3 Effects of Calcium Inhibitory Compounds upon the Cardiovascular System WILLIAM W.

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